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1. (WO2017153432) A NEW UNIVERSAL METHOD TO CAPTURE AND ANALYZE ADCS FOR CHARACTERIZATION OF DRUG DISTRIBUTION AND THE DRUG-TO-ANTIBODY RATIO IN BIOLOGICAL SAMPLES

Pub. No.:    WO/2017/153432    International Application No.:    PCT/EP2017/055362
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Wed Mar 08 00:59:59 CET 2017
IPC: G01N 33/543
G01N 33/68
G01N 33/94
Applicants: PIERRE FABRE MEDICAMENT
Inventors: KLINGUER-HAMOUR, Christine
JANIN-BUSSAT, Marie-Claire
Title: A NEW UNIVERSAL METHOD TO CAPTURE AND ANALYZE ADCS FOR CHARACTERIZATION OF DRUG DISTRIBUTION AND THE DRUG-TO-ANTIBODY RATIO IN BIOLOGICAL SAMPLES
Abstract:
The present invention relates to a new method for capturing and analysing antibody- drug conjugates (ADCs) in biological samples, such as e.g., serum. Methods for analysing the structure of an antibody-drug conjugate (ADC) in a biological sample and methods for assessing the stability of an ADC are also provided.