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1. (WO2017153424) MYO1A FOR PREDICTING CONVERSION OF ACUTE PAIN INTO CHRONIC PAIN AND USE OF MYO1A FOR THERAPY OF PAIN

Pub. No.:    WO/2017/153424    International Application No.:    PCT/EP2017/055354
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Wed Mar 08 00:59:59 CET 2017
IPC: C12Q 1/68
A61K 31/7088
A61K 31/713
G01N 33/50
A01K 67/027
Applicants: UNIVERSITE D'AIX-MARSEILLE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors: MOQRICH, Abdelaziz
Title: MYO1A FOR PREDICTING CONVERSION OF ACUTE PAIN INTO CHRONIC PAIN AND USE OF MYO1A FOR THERAPY OF PAIN
Abstract:
The present invention relates to the identification of Myo1a as a biomarker of conversion of acute pain into chronic pain, and as a therapeutic target. The invention in particular relates to products and methods for assessing the predisposition of a subject to develop an injury-induced chronic mechanical pain and/or an inflammatory-induced chronic thermal pain, and is particularly suited for mammals, preferably human subjects. The present invention more specifically relates to the assessment of the predisposition of a subject to develop an injury-induced chronic mechanical pain and/or an inflammatory-induced chronic thermal pain using preferably the MYO1A gene as a biomarker. Inventors herein provide binding reagents specific for MYO1A, compositions, devices, kits containing the same and animal model, and further describe their uses for assessing the predisposition of a subject to suffer from chronic pain. The invention also relates to products and methods for diagnosing, preventing, managing or treating chronic pain.