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1. (WO2017153336) DETECTION OF ANTI-P53 ANTIBODIES

Pub. No.:    WO/2017/153336    International Application No.:    PCT/EP2017/055190
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Mar 07 00:59:59 CET 2017
IPC: G01N 33/574
C07K 14/47
Applicants: F. HOFFMANN-LA ROCHE AG
ROCHE DIAGNOSTICS GMBH
ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventors: ANDRES, Herbert
KARL, Johann
KUNERT, Ursula
MORGENSTERN, David
MEISSLER, Nina
NIESSNER, Marion
SWIATEK-DE LANGE, Magdalena
Title: DETECTION OF ANTI-P53 ANTIBODIES
Abstract:
The disclosure relates to an in vitro method for detecting an antibody to p53 (anti-p53 antibody) in a sample, the method comprising: incubating a sample to be analyzed with a p53 capture antigen and a p53 detection antigen, whereby a complex comprising the p53 capture antigen, the anti-p53 antibody and the p53 detection antigen is formed, separating the complex formed from unbound detection antigen and measuring the complex obtained via the detection antigen comprised therein, thereby detecting the anti-p53 antibody comprised in the sample.