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1. (WO2017153316) DRUG DELIVERY PARTICLES

Pub. No.:    WO/2017/153316    International Application No.:    PCT/EP2017/055147
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Tue Mar 07 00:59:59 CET 2017
IPC: A61K 39/102
A61K 9/16
Applicants: GLAXOSMITHKLINE BIOLOGICALS SA
LIQUIDIA TECHNOLOGIES, INC.
Inventors: ELOUAHABI, Abdelatif A.
POHLHAUS, Patrick
STRODIOT, Laurent Bernard Jean
GALLOWAY, Ashley
LEE, Jin
STONE, Michele R.
Title: DRUG DELIVERY PARTICLES
Abstract:
The present invention concerns drug delivery particles which can prevent interaction between a biologically-active cargo comprised within the particles and components of an aqueous environment in which said particles are present. The particles are sensitive to p H such that above a threshold p H level the biologically-active cargo becomes accessible to the surrounding environment. Such particles are accordingly useful for stably storing a biologically-active cargo in an aqueous composition containing components which would otherwise interact deleteriously with the cargo, and releasing the cargo to mediate a biological effect in the body of an animal, such as a human, to which the composition is administered. Also provided are compositions comprising such particles, as well as methods for making and using such particles and compositions.