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1. (WO2017153220) 2—AMINO—N— [7—METHOXY—2, 3-DIHYDROIMIDAZO-[1, 2-C] QUINAZOLIN-5-YL] PYRIMIDINE—5—CARBOXAMIDES
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Pub. No.: WO/2017/153220 International Application No.: PCT/EP2017/054736
Publication Date: 14.09.2017 International Filing Date: 01.03.2017
IPC:
C07D 487/04 (2006.01) ,A61K 31/5377 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/00 (2006.01) ,A61P 9/00 (2006.01) ,A61P 3/00 (2006.01) ,A61P 27/02 (2006.01) ,A61P 17/06 (2006.01) ,A61P 7/02 (2006.01) ,A61K 31/519 (2006.01)
[IPC code unknown for C07D 487/04][IPC code unknown for A61K 31/5377][IPC code unknown for A61P 35][IPC code unknown for A61P 37][IPC code unknown for A61P 9][IPC code unknown for A61P 3][IPC code unknown for A61P 27/02][IPC code unknown for A61P 17/06][IPC code unknown for A61P 7/02][IPC code unknown for A61K 31/519]
Applicants:
BAYER PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstr. 178 13353 Berlin, DE
Inventors:
SCHWARZ, Thomas; DE
LIU, Ningshu; DE
POLITZ, Oliver; DE
GERISCH, Michael; DE
LANG, Dieter; DE
Agent:
BIP PATENTS; Alfred-Nobel-Str. 10 40789 Monheim am Rhein, DE
Priority Data:
16159156.508.03.2016EP
Title (EN) 2—AMINO—N— [7—METHOXY—2, 3-DIHYDROIMIDAZO-[1, 2-C] QUINAZOLIN-5-YL] PYRIMIDINE—5—CARBOXAMIDES
(FR) 2-AMINO-N-[7-MÉTHOXY-2,3-DIHYDROIMIDAZO-[1,2-C]QUINAZOLIN-5-YL]PYRIMIDINE-5-CARBOXAMIDES
(DE) 2-AMINO-N-[7-METHOXY-2,3-DIHYDROIMIDAZO-[1,2-C]QUINAZOLIN-5-YL]PYRIMIDINE-5-CARBOXAMIDES
Abstract:
(EN) This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
(FR) La présente invention concerne de nouvelles 2,3-dihydroimidazo[1,2-c] quinazoline substituées, des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés ou compositions pour l'inhibition de la phosphatidylinositol-3-kinase (PI3K) et le traitement de maladies associées à l'activité de la phosphatidylinositol-3-kinase (PI3K), en particulier le traitement de troubles hyperprolifératifs et/ou de l'angiogenèse, en tant qu'agent unique ou en combinaison avec d'autres principes actifs.
(DE) This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)