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1. (WO2017153186) SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS

Pub. No.:    WO/2017/153186    International Application No.:    PCT/EP2017/054324
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Feb 25 00:59:59 CET 2017
IPC: C07D 519/00
C07D 473/34
C07D 487/04
C07H 19/06
C07H 19/16
A61K 31/519
A61K 31/52
A61P 29/00
A61P 35/00
A61P 37/00
Applicants: JANSSEN PHARMACEUTICA NV
Inventors: BERTHELOT, Didier Jean-Claude
BREHMER, Dirk
BEKE, Lijs
BOECKX, An
DIELS, Gaston Stanislas Marcella
GILISSEN, Ronaldus Arnodus Hendrika Joseph
LAWSON, Edward Charles
PANDE, Vineet
PARADÉ, Marcus Cornelis Bernardus Catharina
SCHEPENS, Wim Bert Griet
SHOOK, Brian Christopher
THURING, Johannes Wilhelmus John F.
VIELLEVOYE, Marcel
SUN, Weimei
WU, Tongfei
MEERPOEL, Lieven
Title: SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS
Abstract:
The present invention relates novel substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.