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|1. (WO2017153186) SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS|
|Applicants:||JANSSEN PHARMACEUTICA NV
|Inventors:||BERTHELOT, Didier Jean-Claude
DIELS, Gaston Stanislas Marcella
GILISSEN, Ronaldus Arnodus Hendrika Joseph
LAWSON, Edward Charles
PARADÉ, Marcus Cornelis Bernardus Catharina
SCHEPENS, Wim Bert Griet
SHOOK, Brian Christopher
THURING, Johannes Wilhelmus John F.
|Title:||SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS|
The present invention relates novel substituted nucleoside analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.