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1. (WO2017153023) IN VITRO METHOD FOR IDENTIFYING THORACIC AORTIC ANEURYSMS (TAA) IN A SUBJECT

Pub. No.:    WO/2017/153023    International Application No.:    PCT/EP2016/082925
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sat Dec 31 00:59:59 CET 2016
IPC: G01N 33/68
Applicants: CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS
UNIVERSIDAD AUTÓNOMA DE MADRID
Inventors: REDONDO MOYA, Juan Miguel
MÉNDEZ-BARBERO, Nerea
OLLER PEDROSA, Jorge
CAMPANERO GARCÍA, Miguel Ramón
Title: IN VITRO METHOD FOR IDENTIFYING THORACIC AORTIC ANEURYSMS (TAA) IN A SUBJECT
Abstract:
The present invention refers to an In vitro method for screening for subjects at risk of developing thoracic aortic aneurysm (TAA) or a disease causing TAA comprising: (a) measuring the expression pattern or level of at least A Disintegrin And Metalloproteinase with Thrombospondin Motifs 1 (ADAMTS1) obtained from an isolated biological sample of the subjects to be screened; and (b) comparing said expression pattern or level of at least ADAMTS1 of the subjects to be screened with an already established expression pattern or level, wherein reduced expression of at least ADAMTS1 is indicative of a thoracic aortic aneurysm (TAA).