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1. (WO2017152861) CONJUGATES OF ISLET NEOGENESIS PEPTIDES AND ANALOGS, AND METHODS THEREOF

Pub. No.:    WO/2017/152861    International Application No.:    PCT/CN2017/076190
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: C07K 14/47
A61K 38/26
A61K 38/22
Applicants: SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.
Inventors: LIU, Liping
BAI, Ru
Title: CONJUGATES OF ISLET NEOGENESIS PEPTIDES AND ANALOGS, AND METHODS THEREOF
Abstract:
Disclosed herein are novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and conditions, particularly diseases and conditions relating to diabetes. The compounds are also useful for treating impaired pancreatic function, treating metabolic diseases, ex/vivo isle-tinduction, expansion and proliferation for transplantation, increasing the survival of transplanted islets in vivo, promoting neuroprotection or nerve regeneration, promoting liver regeneration, and inhibiting inflammation.