Search International and National Patent Collections
|1. (WO2017152858) CRYSTAL FORM OF CERITINIB AND PREPARATION METHOD THEREOF|
|Applicants:||CRYSTAL PHARMATECH CO., LTD
|Title:||CRYSTAL FORM OF CERITINIB AND PREPARATION METHOD THEREOF|
The present invention relates to crystal form II of 5-chlorine-N2-(2-isopropoxy-5-methyl-4-piperidine-4-yl-phenyl)-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (ceritinib), and the present invention also relates to the method for preparing the crystal form, the pharmaceutical composition comprising the crystal form and the method for treating diseases with the crystal form and the pharmaceutical composition. The crystal form provided by the present invention has advantageous performances, such as a good stability, relatively low hygroscopicity, exploitability and strong treatability of process, and the preparation method is simple, is low cost, and has an important value for the optimization and development of the drug in the future.