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1. (WO2017152858) CRYSTAL FORM OF CERITINIB AND PREPARATION METHOD THEREOF

Pub. No.:    WO/2017/152858    International Application No.:    PCT/CN2017/076179
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: C07D 401/12
A61K 31/506
A61P 35/00
Applicants: CRYSTAL PHARMATECH CO., LTD
苏州晶云药物科技有限公司
Inventors: CHEN, Minhua
陈敏华
ZHANG, Yanfeng
张炎锋
DIAO, Xiaojuan
刁小娟
ZHANG, Xiaoyu
张晓宇
Title: CRYSTAL FORM OF CERITINIB AND PREPARATION METHOD THEREOF
Abstract:
The present invention relates to crystal form II of 5-chlorine-N2-(2-isopropoxy-5-methyl-4-piperidine-4-yl-phenyl)-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (ceritinib), and the present invention also relates to the method for preparing the crystal form, the pharmaceutical composition comprising the crystal form and the method for treating diseases with the crystal form and the pharmaceutical composition. The crystal form provided by the present invention has advantageous performances, such as a good stability, relatively low hygroscopicity, exploitability and strong treatability of process, and the preparation method is simple, is low cost, and has an important value for the optimization and development of the drug in the future.