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1. (WO2017152857) INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR CONTAINING NITROGEN ALKYLATED AND ARYLATED SULPHOXIDE IMINES

Pub. No.:    WO/2017/152857    International Application No.:    PCT/CN2017/076160
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Fri Mar 10 00:59:59 CET 2017
IPC: C07D 271/08
A61K 31/4245
A61P 29/00
A61P 35/00
A61P 25/00
A61P 27/02
A61P 25/24
A61P 25/22
A61P 25/28
A61P 37/06
Applicants: SHANGAHI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES
中国科学院上海有机化学研究所
Inventors: WANG, Zhaoyin
王召印
GUO, Wei
郭巍
ZHU, Jidong
朱继东
HU, Xinbo
胡新波
Title: INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR CONTAINING NITROGEN ALKYLATED AND ARYLATED SULPHOXIDE IMINES
Abstract:
Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor and a preparation method therefor. The structure of the inhibitor of the present invention is shown in general formula (I), wherein the definitions of X, R1, R2, R3, R4, R7, R8, R9, n and m are as shown in the description and the claims. Also disclosed in the present invention is a preparation method for the inhibitor. The compound in general formula (I) of the present invention can be used as an indoleamine-2,3-dioxygenase inhibitor for the preparation of a drug for preventing and/or treating diseases mediated by indoleamine-2,3-dioxygenase.