Search International and National Patent Collections

1. (WO2017152846) CRYSTAL FORM A OF 2-[(2R)-2-METHYL-2-PYRROLIDYL]-1H-BENZIMIDAZOLE-7-CARBOXAMIDE DIHYDROCHLORIDE AND PREPARATION METHOD THEREOF

Pub. No.:    WO/2017/152846    International Application No.:    PCT/CN2017/075990
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 09 00:59:59 CET 2017
IPC: C07D 403/04
A61K 31/4184
A61P 35/00
Applicants: CRYSTAL PHARMATECH CO., LTD.
苏州晶云药物科技有限公司
Inventors: CHEN, Minhua
陈敏华
ZHANG, Yanfeng
张炎锋
LIU, Kai
刘凯
ZHANG, Xiaoyu
张晓宇
Title: CRYSTAL FORM A OF 2-[(2R)-2-METHYL-2-PYRROLIDYL]-1H-BENZIMIDAZOLE-7-CARBOXAMIDE DIHYDROCHLORIDE AND PREPARATION METHOD THEREOF
Abstract:
Provided are a crystal form A of 2-[(2R)-2-methyl-2-pyrrolidyl]-1H-benzimidazole-7-carboxamide dihydrochloride and the preparation method and use thereof. An X-ray powder diffractogram of crystal form A has a characteristic peak at the following 2θ-diffraction angles: 8.3°±0.2°, 26.7°±0.2° and 16.1°±0.2°. Crystal form A, compared with the existing crystal form, has a surprisingly excellent solubility, mechanical and storage stabilities and particle size distribution, is a more ideal crystal form compared with the reported crystal forms, better satisfies medicinal requirements, and has an important value for the optimization and development of the drug in the future.