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|1. (WO2017152846) CRYSTAL FORM A OF 2-[(2R)-2-METHYL-2-PYRROLIDYL]-1H-BENZIMIDAZOLE-7-CARBOXAMIDE DIHYDROCHLORIDE AND PREPARATION METHOD THEREOF|
|Applicants:||CRYSTAL PHARMATECH CO., LTD.
|Title:||CRYSTAL FORM A OF 2-[(2R)-2-METHYL-2-PYRROLIDYL]-1H-BENZIMIDAZOLE-7-CARBOXAMIDE DIHYDROCHLORIDE AND PREPARATION METHOD THEREOF|
Provided are a crystal form A of 2-[(2R)-2-methyl-2-pyrrolidyl]-1H-benzimidazole-7-carboxamide dihydrochloride and the preparation method and use thereof. An X-ray powder diffractogram of crystal form A has a characteristic peak at the following 2θ-diffraction angles: 8.3°±0.2°, 26.7°±0.2° and 16.1°±0.2°. Crystal form A, compared with the existing crystal form, has a surprisingly excellent solubility, mechanical and storage stabilities and particle size distribution, is a more ideal crystal form compared with the reported crystal forms, better satisfies medicinal requirements, and has an important value for the optimization and development of the drug in the future.