Search International and National Patent Collections

1. (WO2017152706) SALT OF PYRIDINYL AMINO PYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Pub. No.:    WO/2017/152706    International Application No.:    PCT/CN2017/000202
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Thu Mar 02 00:59:59 CET 2017
IPC: C07D 401/14
A61K 31/506
A61P 35/00
A61P 35/04
Applicants: SHANGHAI ALLIST PHARMACEUTICAL AND MEDICAL TECHNOLOGY CORPORATIONS
上海艾力斯医药科技有限公司
Inventors: LUO, Huibing
罗会兵
ZHOU, Huayong
周华勇
Title: SALT OF PYRIDINYL AMINO PYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Abstract:
A mesylate salt of a compound represented by formula (I) and preparation method therefor, a pharmaceutical composition containing the salt, and an application of the salt in the treatment of activated EGFR mutant- or drug-resistant mutant-mediated diseases, especially cancer, in mammals, particularly humans. The mesylate salt of the compound represented by formula (I) has high bioavailability in animals, can better inhibit the growth of transplanted tumors in animals, and demonstrates desirable safety.