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1. (WO2017152447) RGD PEPTIDE AND PENETRATING PEPTIDE R8 CO-MODIFIED ERGOSTEROL AND CISPLATIN ACTIVE DRUG-LOADING LIPOSOME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/152447 International Application No.: PCT/CN2016/078429
Publication Date: 14.09.2017 International Filing Date: 05.04.2016
IPC:
A61K 33/24 (2006.01) ,A61K 31/575 (2006.01) ,A61K 47/42 (2017.01) ,A61K 9/127 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575
substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
Applicants:
浙江中医药大学 ZHEJIANG CHINESE MEDICAL UNIVERSITY [CN/CN]; 中国浙江省杭州市 滨江区滨文路548号 No. 548 Binwen Road, Binjiang District Hangzhou, Zhejiang 310053, CN
Inventors:
黄绳武 HUANG, Shengwu; CN
黄挺 HUANG, Ting; CN
吴梅佳 WU, Meijiang; CN
赵丹丹 ZHAO, Dandan; CN
Agent:
杭州杭诚专利事务所有限公司 HANGZHOU HANGCHENG PATENT ATTORNEY OFFICE CO., LTD; 中国浙江省杭州市 西湖大道35号万新大厦1号楼505室 Rm. 505, No.1 Wanxin Building No. 35 Xihu Road Hangzhou, Zhejiang 310009, CN
Priority Data:
201610141181.911.03.2016CN
Title (EN) RGD PEPTIDE AND PENETRATING PEPTIDE R8 CO-MODIFIED ERGOSTEROL AND CISPLATIN ACTIVE DRUG-LOADING LIPOSOME
(FR) LIPOSOME À BASE D'ERGOSTÉROL ET CHARGÉ AVEC LE PRINCIPE ACTIF CISPLATINE, CO-MODIFIÉ PAR LE PEPTIDE RGD ET LE PEPTIDE PÉNÉTRANT R8
(ZH) 一种RGD肽与穿膜肽R8共修饰麦角甾醇联合顺铂主动载药脂质体
Abstract:
(EN) An RGD peptide and penetrating peptide R8 co-modified ergosterol and cisplatin active drug-loading liposome is prepared by means of incubation of an ergosterol and cisplatin active drug-loading liposome, RGD cyclic peptide and penetrating peptide R8 in a water bath. The ergosterol and cisplatin active drug-loading liposome is prepared from an ergosterol liposome and a cisplatin solution serving as raw materials, the ergosterol liposome is prepared from 8 wt% to 15 wt% of ergosterol and 85 wt% to 92 wt% of liposomes, and the liposomes consist of lecithin and cholesterol.
(FR) L'invention concerne un liposome à base d'ergostérol et chargé avec le principe actif cisplatine, co-modifié par le peptide RGD et le peptide pénétrant R8, qui est préparé en incubant dans un bain d'eau un liposome à base d'ergostérol et chargé avec le principe actif cisplatine, le peptide cylique RGD et le peptide pénétrant R8. Le liposome à base d'ergostérol et chargé avec le principe actif cisplatine est préparé à partir d'un liposome à base d'ergostérol et d'une solution de cisplatine servant de matières premières, le liposome à base d'ergostérol étant préparé à partir de 8 % en poids d'ergostérol et de 85 % à 92 % en poids de liposomes, les liposomes étant constitués de lécithine et de cholestérol.
(ZH) 一种RGD肽与穿膜肽R8共修饰麦角甾醇联合顺铂主动载药脂质体,由麦角甾醇联合顺铂主动载药脂质体、RGD环肽及穿膜肽R8在水浴中孵育后制备而得。所述麦角甾醇联合顺铂主动载药脂质体由麦角甾醇脂质体、顺铂溶液为原料制成。所述麦角甾醇脂质体由麦角甾醇8-15wt%和脂质体85-92wt%制成,所述脂质体由卵磷脂与胆固醇组成。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)