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1. (WO2017152302) LIVER INJURY TARGETED MESENCHYMAL STEM CELL, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF

Pub. No.:    WO/2017/152302    International Application No.:    PCT/CN2016/075711
Publication Date: Fri Sep 15 01:59:59 CEST 2017 International Filing Date: Sun Mar 06 00:59:59 CET 2016
IPC: C12N 5/10
C12N 15/86
C12N 15/88
A61K 35/28
A61P 1/16
C12N 5/077
Applicants: ZHANGJIAGANG INSTITUTE OF INDUSTRIAL TECHNOLOGIES SOOCHOW UNIVERSITY
苏州大学张家港工业技术研究院
Inventors: HE, Lihong
贺丽虹
ZHANG, Huanxiang
张焕相
XU, Jianwei
许键炜
Title: LIVER INJURY TARGETED MESENCHYMAL STEM CELL, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF
Abstract:
Provided are a liver injury targeted mesenchymal stem cell, a preparation method therefor, and applications thereof in the preparation of drugs for treating liver injuries. The cell is prepared by transfecting a mesenchymal stem cell or infecting a nucleic acid, the nucleic acid being miR-26b. To further improve the efficiency of mesenchymal stem cells targeting for a liver injury part and improve the recovery effect of a liver function and a tissue structure recovery effect, the mesenchymal stem cell can be treated by using basic fibroblast growth factors.