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1. (WO2017152149) CLOSED-ENDED LINEAR DUPLEX DNA FOR NON-VIRAL GENE TRANSFER

Pub. No.:    WO/2017/152149    International Application No.:    PCT/US2017/020828
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: A61K 48/00
C12N 15/09
C12N 15/64
C12N 15/66
Applicants: UNIVERSITY OF MASSACHUSETTS
Inventors: KOTIN, Robert, M.
CECCHINI, Sylvain
Title: CLOSED-ENDED LINEAR DUPLEX DNA FOR NON-VIRAL GENE TRANSFER
Abstract:
Aspects of the disclosure relate to a nucleic acid comprising a heterologous nucleic acid insert flanked by interrupted self-complementary sequences, wherein one self-complementary sequence is interrupted by a cross-arm sequence forming two opposing, lengthwise- symmetric stem-loops, and wherein the other of the self-complementary sequences is interrupted by a truncated cross-arm sequence. Methods of delivering the nucleic acid to a cell are also provided.