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1. (WO2017152127) MRI AND CT CONTRAST-ENABLED COMPOSITE IMPLANTS FOR IMAGE-GUIDED TISSUE REGENERATION AND THERAPY

Pub. No.:    WO/2017/152127    International Application No.:    PCT/US2017/020793
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: A61K 49/04
A61K 51/00
Applicants: AMRITA VISHWA VIDYAPEETHAM
KOYAKUTTY, Manzoor
MEETHALEVEEDU, Sajesh
ASHOKAN, Anusha
SOMASUNDARAM, Vijay Harish
NAIR, Shantikumar
Inventors: KOYAKUTTY, Manzoor
MEETHALEVEEDU, Sajesh
ASHOKAN, Anusha
SOMASUNDARAM, Vijay Harish
NAIR, Shantikumar
Title: MRI AND CT CONTRAST-ENABLED COMPOSITE IMPLANTS FOR IMAGE-GUIDED TISSUE REGENERATION AND THERAPY
Abstract:
A composite implant (100) for providing simultaneous magnetic resonance imaging (MRI) and computed tomographic (CT) imaging contrast is disclosed. The composite implant (100) is formed of a calcium compound (120) in the form of nano or microparticles doped with a first dopant (126) configured to provide MRI contrast and a second dopant (127) configured to provide CT contrast. The calcium compound (120) is loaded onto a polymer gel matrix (110) and lyophilized to form a mass with 3-dimensionally interconnected porosity (102), configured to provide tissue integration and proliferation sites. Methods (200) of forming the composite implant (100) are also disclosed. The implant could be a scaffold (101) or bead (105) structured to enable treatment of human or animal patient for bone/cartilage injury or defect by implantation, with MRI and CT monitoring.