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1. (WO2017152117) SMALL MOLECULE IRE1-ALPHA INHIBITORS

Pub. No.:    WO/2017/152117    International Application No.:    PCT/US2017/020773
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: A61P 35/00
C07D 471/04
A61K 31/4155
A61K 31/4406
A61K 31/4439
A61K 31/5025
A61K 31/506
A61K 31/519
C07D 487/04
C07D 401/14
C07D 413/14
A61K 31/4162
A61K 31/4188
A61K 31/423
A61K 31/437
A61K 31/444
A61K 31/4709
A61K 31/4725
A61K 31/497
A61K 31/498
A61K 31/517
A61K 31/536
A61K 31/55
C07D 401/04
C07D 401/10
C07D 403/04
C07D 403/10
C07D 409/14
C07D 413/04
Applicants: CORNELL UNIVERSITY
Inventors: RUIZ, Juan Rodrigo Cubillos
GLIMCHER, Laurie H.
BETTIGOLE, Sarah Elizabeth
VACCA, Joseph P.
Title: SMALL MOLECULE IRE1-ALPHA INHIBITORS
Abstract:
Described herein are IRE1α inhibitors, compositions containing such inhibitors, and methods of treatment that include administration of such compounds. Exemplary compounds are provided throughout the application. Formula Ia