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1. (WO2017152080) LOADING PLATFORM FOR THREE-DIMENSIONAL TISSUE ENGINEERED SCAFFOLDS

Pub. No.:    WO/2017/152080    International Application No.:    PCT/US2017/020706
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: A61K 35/12
A61L 27/38
A61L 27/44
A61L 27/54
A61L 27/60
C12M 3/00
C12N 5/00
Applicants: THE UNIVERSITY OF TOLEDO
Inventors: SUBRAMANIAN, Gayathri
ELSAADANY, Mostafa
YILDIRIM-AYAN, Eda
Title: LOADING PLATFORM FOR THREE-DIMENSIONAL TISSUE ENGINEERED SCAFFOLDS
Abstract:
A scaffold-stretching system includes at least one stretchable loading chamber configured to support a scaffold material and a supply of cells, such as human skin substitute cells, and is configured to allow for cultivation of a cellular three-dimensional scaffold; and a mechanical loading system is configured for application of cyclic and static uniaxial tensile mechanical loading on the cellular three-dimensional scaffold, and is configured to mimic the in vivo environment of musculoskeletal, cardiovascular, and other tissues that experience uniaxial strains.