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1. (WO2017152076) SUBSTITUTED INDOLE MCL-1 INHIBITORS

Pub. No.:    WO/2017/152076    International Application No.:    PCT/US2017/020699
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: C07D 209/30
A61K 31/404
Applicants: VANDERBILT UNIVERSITY
Inventors: LEE, Taekyu
TARR, James, C.
JEON, Kyuok
SALOVICH, James, M.
SHAW, Subrata
VEERASAMY, Nagarathanam
KIM, Kwangho
CHRISTOV, Plamen, P.
OLEJNICZAK, Edward, T.
ZHAO, Bin
FESIK, Stephen, W.
BIAN, Zhiguo
Title: SUBSTITUTED INDOLE MCL-1 INHIBITORS
Abstract:
The present disclosure provides for compounds that inhibit the activity of an anti- apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over- expression or dysregulation of Mcl-1 protein.