Search International and National Patent Collections
|1. (WO2017152076) SUBSTITUTED INDOLE MCL-1 INHIBITORS|
TARR, James, C.
SALOVICH, James, M.
CHRISTOV, Plamen, P.
OLEJNICZAK, Edward, T.
FESIK, Stephen, W.
|Title:||SUBSTITUTED INDOLE MCL-1 INHIBITORS|
The present disclosure provides for compounds that inhibit the activity of an anti- apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over- expression or dysregulation of Mcl-1 protein.