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1. (WO2017152039) PROTECTION AND DELIVERY OF MULTIPLE THERAPEUTIC PROTEINS

Pub. No.:    WO/2017/152039    International Application No.:    PCT/US2017/020642
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: A61K 9/10
A61K 9/06
A61K 47/30
A61K 35/19
A61L 15/22
A61L 15/44
A61L 15/26
Applicants: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Inventors: JEFFRIES, Eric, M.
JOHNSON, Noah, R.
LONG, Daniel
WANG, Yadong
Title: PROTECTION AND DELIVERY OF MULTIPLE THERAPEUTIC PROTEINS
Abstract:
Compositions are provided herein comprising a coacervate of a polycationic polymer, a polyanionic polymer, and platelet-rich plasma and/or serum, or a fraction or concentrate thereof. The composition is useful in wound healing. Compositions also are provided that comprise a hydrogel comprising TIMP-3; and a complex of a polycationic polymer, a polyanionic polymer, FGF-2 and SDF-1α embedded in the hydrogel, which is useful in treating a myocardial infarction.