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1. (WO2017152027) METHOD OF TREATING AN EYE DISORDER BY INHIBITING OR DISRUPTING BACTERIAL BIOFILM FORMATION

Pub. No.:    WO/2017/152027    International Application No.:    PCT/US2017/020618
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: A61K 31/00
A61K 33/00
A61K 35/66
A61K 36/00
C07K 16/12
Applicants: RYNERSON, James, M.
Inventors: RYNERSON, James, M.
Title: METHOD OF TREATING AN EYE DISORDER BY INHIBITING OR DISRUPTING BACTERIAL BIOFILM FORMATION
Abstract:
The present invention relates to methods of treating blepharitis and dry eye by inhibiting the binding ability of lid flora bacteria such as Staphylococcus aureus and Staphylococcus epidermidis, thus inhibiting biofilm formation and the increase in bacterial populations and densities that lead to quorum-sensing-gene activation and therefore, the production of inflammatory virulence factors.