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1. (WO2017152023) FEL D 1 KNOCKOUTS AND ASSOCIATED COMPOSITIONS AND METHODS BASED ON CRISPR-CAS9 GENOMIC EDITING

Pub. No.:    WO/2017/152023    International Application No.:    PCT/US2017/020609
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: A61K 38/46
C12N 9/22
C12N 15/87
C12N 15/90
C12N 9/12
C07K 14/435
Applicants: INDOOR BIOTECHNOLOGIES INC.
CHAPMAN, Martin D.
SPASSIBOJKO, Olya
Inventors: CHAPMAN, Martin D.
SPASSIBOJKO, Olya
Title: FEL D 1 KNOCKOUTS AND ASSOCIATED COMPOSITIONS AND METHODS BASED ON CRISPR-CAS9 GENOMIC EDITING
Abstract:
Compositions and methods for genetically modifying felines or feline cells are described. The compositions and methods are useful for knocking out all or a portion of a Fel d 1 gene from a feline genome. Feline cells and organisms in which all or a portion of the Fel d 1 gene is knocked out are also described. The compositions and methods may include reagents and procedures for CRISPR-Cas9-mediated genomic editing of Fel d 1.