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1. (WO2017151978) LIVE-CELL COMPUTED TOMOGRAPHY

Pub. No.:    WO/2017/151978    International Application No.:    PCT/US2017/020528
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Fri Mar 03 00:59:59 CET 2017
IPC: G01N 23/04
Applicants: ARIZONA BOAD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Inventors: MELDRUM, Deirdre
JOHNSON, Roger
KELBAUSKAS, Laimonas
HOUKAL, Jeff
ASHCROFT, Brian
SMITH, Dean
WANG, Hong
CHAO, (Joseph), Shih-Hui
RISHABH, Shetty
MYERS, Jakrey
ELANGO, Iniyan, Soundappa
Title: LIVE-CELL COMPUTED TOMOGRAPHY
Abstract:
Systems and methods of using the same for functional fluorescence imaging of live cells in suspension with isotropic three dimensional (3D) diffraction-limited spatial resolution are disclosed. The method-live cell computed tomography (LCCT)-involves the acquisition of a series of two dimensional (2D) pseudo-projection images from different perspectives of the cell that rotates around an axis that is perpendicular to the optical axis of the imaging system. The volumetric image of the cell is then tomographically reconstructed.