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|1. (WO2017151922) STING ACTIVATING NANOVACCINE FOR IMMUNOTHERAPY|
|Applicants:||THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
|Title:||STING ACTIVATING NANOVACCINE FOR IMMUNOTHERAPY|
In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer has a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.