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1. (WO2017151922) STING ACTIVATING NANOVACCINE FOR IMMUNOTHERAPY

Pub. No.:    WO/2017/151922    International Application No.:    PCT/US2017/020451
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Fri Mar 03 00:59:59 CET 2017
IPC: A61K 9/51
A61K 47/30
A61K 48/00
G01N 21/76
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Inventors: GAO, Jinming
CHEN, Zhijian
LUO, Min
WANG, Zhaohui
WANG, Hua
CAI, Haocheng
HUANG, Gang
FU, Yang-Xin
Title: STING ACTIVATING NANOVACCINE FOR IMMUNOTHERAPY
Abstract:
In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer has a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.