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1. (WO2017151909) METHODS FOR CONTROLLED PROLIFERATION OF VESTIBULAR STEM CELLS / GENERATING INNER EAR HAIR CELLS USING WNT AND TGF-BETA INHIBITION
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Pub. No.: WO/2017/151909 International Application No.: PCT/US2017/020437
Publication Date: 08.09.2017 International Filing Date: 02.03.2017
IPC:
A61K 35/12 (2015.01) ,C12N 5/07 (2010.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
Applicants:
FREQUENCY THERAPEUTICS, INC. [US/US]; 300 Technology Square, 8th Floor Cambridge, Massachusetts 02139, US
Inventors:
MCLEAN, Will; US
Agent:
ROGEL, Mark, E.; US
LAHERTY, Carol; US
CHRISTIANSEN, William T.; US
FULLER, Alyson C.; US
MASHRUWALA, Mary Anne; US
NUDELMAN, Aaron S.; US
NGUYEN, Thu; US
TEAGUE, Lawrence; US
PHELAN, Jordan D.; US
Priority Data:
62/302,79902.03.2016US
62/303,03503.03.2016US
Title (EN) METHODS FOR CONTROLLED PROLIFERATION OF VESTIBULAR STEM CELLS / GENERATING INNER EAR HAIR CELLS USING WNT AND TGF-BETA INHIBITION
(FR) PROCÉDÉS DE PROLIFÉRATION CONTRÔLÉE DE CELLULES SOUCHES VESTIBULAIRES/DE PRODUCTION DE CELLULES CILIÉES DE L'OREILLE INTERNE À L'AIDE DE L'INHIBITION DE WNT ET DE TGF-BÊTA
Abstract:
(EN) Provided are compositions and methods for using Wnt agonist, GSK3-alpha inhibitor, or GSK3-beta inhibitors in combination with TGF-beta inhibitors to induce the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining in the daughter cells the capacity to differentiate into hair cells.
(FR) L'invention concerne des compositions et des procédés d'utilisation d'un agoniste de Wnt, d'un inhibiteur de GSK3-alpha ou d'inhibiteurs de GSK3-bêta en combinaison avec des inhibiteurs de TGF-bêta pour induire l'auto-renouvellement de cellules de souches/progénitrices de support, consistant à induire la prolifération des cellules souches/progénitrices tout en maintenant dans les cellules filles la capacité à se différencier en cellules ciliées.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)