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1. (WO2017151907) METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK-3-ALPHA INHIBITORS
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Pub. No.: WO/2017/151907 International Application No.: PCT/US2017/020434
Publication Date: 08.09.2017 International Filing Date: 02.03.2017
IPC:
A61K 31/427 (2006.01) ,A61K 31/428 (2006.01) ,A61K 31/5377 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
428
condensed with carbocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
Applicants:
FREQUENCY THERAPEUTICS, INC. [US/US]; 300 Technology Square, 8th Floor Cambridge, Massachusetts 02139, US
Inventors:
LOOSE, Christopher; US
MCLEAN, Will; US
HARRISON, Megan; US
Agent:
ROGEL, Mark E.; US
LAHERTY, Carol; US
CHRISTIANSEN, William T.; US
FULLER, Alyson C.; US
MASHRUWALA, Mary Anne; US
NUDELMAN, Aaron S.; US
NGUYEN, Thu; US
TEAGUE, Lawrence; US
PHELAN, Jordan D.; US
Priority Data:
62/302,80302.03.2016US
62/303,09903.03.2016US
Title (EN) METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK-3-ALPHA INHIBITORS
(FR) MÉTHODES DE RÉGULATION DE LA PROLIFÉRATION DE CELLULES SOUCHES / DE LA GÉNÉRATION DE CELLULES AUDITIVES DE L'OREILLE INTERNE À L'AIDE D'INHIBITEURS DE LA GSK-3-ALPHA
Abstract:
(EN) Provided are compositions and methods for inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells, and including compositions and methods of using GSK3-alpha inhibitors, and salts thereof, optionally in combination with a Differentiation Inhibitor such as a Notch agonist or an HDAC inhibitor (e.g., valproic acid).
(FR) L'invention concerne des compositions et des méthodes permettant d'induire l'auto-renouvellement de cellules souches/progénitrices de support, y compris d'induire la prolifération des cellules souches/progénitrices tout en maintenant, dans les cellules filles, la capacité à se différencier en cellules auditives, et notamment des compositions et des méthodes d'utilisation d'inhibiteurs de la GSK3-alpha, et des sels de ceux-ci, éventuellement en combinaison avec un inhibiteur de différenciation tel qu'un agoniste de Notch ou un inhibiteur de HDAC (par exemple, de l'acide valproïque).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)