Disclosed is a system and device that applies a cascade-effects on one or more parameters relating to a condition of a patient. A complete system approach in both identifying and treating disease is disclosed. This medical approach addresses all counterbalance mechanisms the body uses to regain homeostasis, including their timing cycles. The systems and methods can be a primary system for evidenced based medical treatment. The same system is fully applicable to any and all fields, such as programming, cyber security, military strategies, economics, etc.