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1. (WO2017151860) HUMAN KYNURENINASE ENZYME VARIANTS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES

Pub. No.:    WO/2017/151860    International Application No.:    PCT/US2017/020355
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Fri Mar 03 00:59:59 CET 2017
IPC: C07K 14/725
A61K 35/17
A61K 38/46
C07K 14/705
C07K 16/28
C12N 9/14
C12N 9/96
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Inventors: GEORGIOU, George
STONE, Everett
BLAZECK, John
Title: HUMAN KYNURENINASE ENZYME VARIANTS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES
Abstract:
Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.