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1. (WO2017151791) MATERIALS AND METHODS FOR MITIGATING IMMUNE-SENSITIZATION
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Pub. No.: WO/2017/151791 International Application No.: PCT/US2017/020235
Publication Date: 08.09.2017 International Filing Date: 01.03.2017
IPC:
A61K 38/16 (2006.01) ,A61K 38/47 (2006.01) ,A61K 38/43 (2006.01) ,A61K 39/385 (2006.01) ,A61K 39/39 (2006.01) ,A61K 47/66 (2017.01) ,A61K 47/64 (2017.01) ,A61K 47/50 (2017.01) ,C07K 14/42 (2006.01) ,C12N 9/24 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
47
acting on glycosyl compounds (3.2), e.g. cellulases, lactases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
385
Haptens or antigens, bound to carriers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
[IPC code unknown for A61K 47/66][IPC code unknown for A61K 47/64][IPC code unknown for A61K 47/50]
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
415
from plants
42
Lectins, e.g. concanavalin, phytohaemagglutinin
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
24
acting on glycosyl compounds (3.2)
Applicants:
BIOSTRATEGIES LC [US/US]; PO Box 2428 State University, AR 72467, US
Inventors:
RADIN, David, N.; US
ACOSTA, Walter; US
Agent:
PACE, Doran, R.; US
PACE, Doran, R.; US
LLOYD, Jeff; US
SALIWANCHIK, David, R.; US
EISENSCHENK, Frank, C.; US
Priority Data:
62/301,97301.03.2016US
62/456,44308.02.2017US
Title (EN) MATERIALS AND METHODS FOR MITIGATING IMMUNE-SENSITIZATION
(FR) MATÉRIELS ET MÉTHODES POUR CONTRER LA SENSIBILISATION IMMUNITAIRE
Abstract:
(EN) The present invention concerns materials and method for delivery and internalization of an agent into a cell even in the presence of an immune response, such as antibodies or antisera or immune cells that bind to the agent. The agent can be a compound, drug, peptide, protein, nucleic acid, antigen, immunogen, or other biological molecule. In one embodiment, the agent is operatively linked to a lectin-based carrier. The present invention can be used for delivery and cellular internalization of any entity where an immune response to the entity is present or is likely to be produced or developed. The present invention also concerns methods and materials for providing for an adjuvant and carrier for vaccinations of a person or animal. The present invention also concerns a method for treating or preventing a disease or condition in a human or animal wherein the human or animal has produced or will produce an immune response against a therapeutic agent that can treat said disease or condition, the method comprising administering to the human or animal an effective amount of said therapeutic agent operatively linked to a lectin-based carrier.
(FR) La présente invention concerne des matériels et méthodes pour l'administration d'un agent et son internalisation dans une cellule, y compris en présence d'agents de la réponse immunitaire tels que des anticorps, des antisérums ou des cellules immunitaires, qui se lient à l'agent. L'agent peut être un composé, un médicament, un peptide, une protéine, un acide nucléique, un antigène, un agent immunogène ou une autre molécule biologique. Dans un mode de réalisation, l'agent est lié fonctionnellement à un vecteur à base de lectine. La présente invention peut être utilisée pour l'administration et l'internalisation cellulaire de toute entité dans les cas où une réponse immunitaire à l'entité est présente, ou est susceptible de se former ou de se développer. La présente invention concerne également des méthodes et des matériels pouvant servir d'adjuvant et de support pour des vaccinations d'une personne ou d'un animal. La présente invention concerne également une méthode de traitement ou de prévention d'une maladie ou d'une affection chez l'homme ou chez l'animal, l'homme ou l'animal ayant développé, ou allant développer, une réponse immunitaire contre un agent thérapeutique capable de traiter ladite maladie ou affection, la méthode comprenant l'administration à l'homme ou à l'animal d'une quantité efficace dudit agent thérapeutique lié fonctionnellement à un vecteur à base de lectine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)