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1. (WO2017151746) DIAMIDE MACROCYCLES HAVING FACTOR XIA INHIBITING ACTIVITY

Pub. No.:    WO/2017/151746    International Application No.:    PCT/US2017/020161
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Thu Mar 02 00:59:59 CET 2017
IPC: C07D 498/10
A61K 31/537
A61P 7/02
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: SHI, Jun
EWING, William R.
PINTO, Donald J.P.
Title: DIAMIDE MACROCYCLES HAVING FACTOR XIA INHIBITING ACTIVITY
Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.