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1. (WO2017151707) L-ASPARAGINASE VARIANTS AND FUSION PROTEINS WITH REDUCED L-GLUTAMINASE ACTIVITY AND ENHANCED STABILITY

Pub. No.:    WO/2017/151707    International Application No.:    PCT/US2017/020090
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Thu Mar 02 00:59:59 CET 2017
IPC: C07K 14/52
A61K 38/50
C12N 9/82
Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Inventors: LAVIE, Arnon
NGUYEN, Hien-Anh
Title: L-ASPARAGINASE VARIANTS AND FUSION PROTEINS WITH REDUCED L-GLUTAMINASE ACTIVITY AND ENHANCED STABILITY
Abstract:
Variant Erwinia chrysanthemi L-asparaginases with reduced L-glutaminase activity and enhanced in vivo circulation are described as are fusion proteins containing an L-asparaginase and three tandem soluble domains of TRAIL for use in the treatment of cancers such as acute lymphoblastic leukemia and acute myeloid leukemia.