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1. (WO2017151674) METHOD OF ENDOGENOUS STEM CELL ACTIVATION FOR TENDON/LIGAMENT OSSEOINTEGRATION

Pub. No.:    WO/2017/151674    International Application No.:    PCT/US2017/020033
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: A61L 27/54
A61L 27/24
Applicants: CEDARS-SINAI MEDICAL CENTER
Inventors: GAZIT, Dan
PELLED, Gadi
KREMEN, Thomas
Title: METHOD OF ENDOGENOUS STEM CELL ACTIVATION FOR TENDON/LIGAMENT OSSEOINTEGRATION
Abstract:
Tendon and ligament injuries are common in orthopaedic clinical practice and cause substantial morbidity in sports and in routine daily activities. While surgical reconstruction is effective, the majority of patients suffer from a prolonged period of recovery because of limited regeneration capacity of the tendon-bone interface. Here, the Inventors have established an approach for promoting tendon/ligament integration. By first recruiting endogenous stem cells to the site of injury, bone morphogenic proteins (BMPs), are then delivered in vivo to promote repair. Significant acceleration of healing via the above methods and compositions leads to fast recovery and return to normal activities, thereby providing new therapeutic avenues for treatment of injuries involving the tendon-bone interface.