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1. (WO2017151651) PHARMACEUTICAL IN SITU GELLING COMPOSITIONS

Pub. No.:    WO/2017/151651    International Application No.:    PCT/US2017/019997
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: A61K 31/7048
A61K 47/34
Applicants: BELMONT UNIVERSITY
Inventors: REED, Kenneth W.
Title: PHARMACEUTICAL IN SITU GELLING COMPOSITIONS
Abstract:
The present disclose generally relates to pharmaceutical in situ gelling compositions comprising an aqueous mixture of an anionic polysaccharide, a source of a polyvalent cation and a polymer. The in situ gelling compositions advantageously form transparent gels upon contact with the tear fluid in the eye and are useful as drug delivery vehicles. The present disclosure also relates to in situ gelling compositions comprising a mixture of high acyl gellan, low acyl gellan and a source of a polyvalent cation. Finally, methods of administering a drug opthalmically are also provided.