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1. (WO2017151617) STAPLED INTRACELLULAR-TARGETING ANTIMICROBIAL PEPTIDES TO TREAT INFECTION

Pub. No.:    WO/2017/151617    International Application No.:    PCT/US2017/019953
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: A61K 38/08
A61K 38/12
C07K 5/12
C07K 14/00
C07K 14/47
Applicants: DANA-FARBER CANCER INSTITUTE, INC.
Inventors: WALENSKY, Loren D.
MOURTADA, Rida
Title: STAPLED INTRACELLULAR-TARGETING ANTIMICROBIAL PEPTIDES TO TREAT INFECTION
Abstract:
Structurally stabilized, e.g., stapled, peptides with the ability to translocate through microbial cell membranes to the interior of microbial cells and exert a biological activity there are provided, as are methods of designing, making and using such peptides.