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1. (WO2017151587) AZA-PEPTIDE ALDEHYDES AND KETONES

Pub. No.:    WO/2017/151587    International Application No.:    PCT/US2017/019900
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: C07K 5/02
A61K 38/00
Applicants: OHIO STATE INNOVATION FOUNDATION
Inventors: EKICI, Ozlem Dogan
HADAD, Christopher
CORRIGAN, Thomas
Title: AZA-PEPTIDE ALDEHYDES AND KETONES
Abstract:
The present disclosure relates to compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the invention include aza-peptide aldehyde and ketone compositions that inhibit proteases. The disclosed compounds, pharmaceutically acceptable salts, pharmaceutically acceptable derivatives, prodrugs, or combinations thereof can be used to treat disease or pathological conditions related to the activity of proteases associated with a specific disease or condition.