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1. (WO2017151582) ARRAY OF MICRO-ELEMENTS FOR HIGH RESOLUTION AND HIGH CONTENT IMAGING AND SORTING OF CELLS

Pub. No.:    WO/2017/151582    International Application No.:    PCT/US2017/019889
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: C12M 1/32
C12M 1/00
C12M 1/12
C12M 1/34
Applicants: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Inventors: ALLBRITTON, Nancy
WANG, Yuli
SIMS, Christopher
DOBES, Nicholas C.
GEBHART, Steven C.
TROTTA, Nicholas Clayton
Title: ARRAY OF MICRO-ELEMENTS FOR HIGH RESOLUTION AND HIGH CONTENT IMAGING AND SORTING OF CELLS
Abstract:
An array of magnetic or paramagnetic micro-elements comprised of polysilsesquioxane is described having ultra-low-autofluorescence and other optical properties to improve microscopic imaging of cells or other objects present on the array. These materials are also amenable to chemical modification allowing surface attachment of affinity capture moieties or chemical reporters for selective binding or analysis of cells, macromolecules or other targets.