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1. (WO2017151573) METHODS FOR MAKING L-GLUFOSINATE

Pub. No.:    WO/2017/151573    International Application No.:    PCT/US2017/019871
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: C12P 9/00
C12P 13/04
C12P 41/00
A01N 57/20
C12N 1/21
C12N 9/10
Applicants: AGRIMETIS, LLC
Inventors: GREEN, Brian Michael
GRADLEY, Michelle Lorraine
Title: METHODS FOR MAKING L-GLUFOSINATE
Abstract:
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.