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|1. (WO2017151502) THERAPEUTIC AND DIAGNOSTIC METHODS FOR CANCER|
FOUNDATION MEDICINE, INC.
FRAMPTON, Garrett, M.
STEPHENS, Philip J.
SUN, James, Xin
|Title:||THERAPEUTIC AND DIAGNOSTIC METHODS FOR CANCER|
The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder cancer, methods of determining whether a patient suffering from bladder cancer is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering from bladder cancer to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from bladder cancer, based on somatic mutation levels of genes of the invention (e.g., somatic mutation levels in a tumor sample obtained from the patient).