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1. (WO2017151502) THERAPEUTIC AND DIAGNOSTIC METHODS FOR CANCER

Pub. No.:    WO/2017/151502    International Application No.:    PCT/US2017/019682
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Tue Feb 28 00:59:59 CET 2017
IPC: C12Q 1/68
Applicants: GENENTECH, INC.
FOUNDATION MEDICINE, INC.
Inventors: BOURGON, Richard
FABRIZIO, David
FINE, Gregg
FRAMPTON, Garrett, M.
HEGDE, Priti
MARIATHASAN, Sanjeev
STEPHENS, Philip J.
SUN, James, Xin
YELENSKY, Roman
Title: THERAPEUTIC AND DIAGNOSTIC METHODS FOR CANCER
Abstract:
The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder cancer, methods of determining whether a patient suffering from bladder cancer is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering from bladder cancer to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from bladder cancer, based on somatic mutation levels of genes of the invention (e.g., somatic mutation levels in a tumor sample obtained from the patient).