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1. (WO2017151487) DETECTION OF GLUA1 IN BRAIN TO IDENTIFY THE PRESENCE OF GLUA1 -MEDIATED PTSD
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Pub. No.: WO/2017/151487 International Application No.: PCT/US2017/019638
Publication Date: 08.09.2017 International Filing Date: 27.02.2017
IPC:
A61K 31/13 (2006.01) ,C07C 13/615 (2006.01) ,C07C 57/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
13
Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
28
Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
32
with condensed rings
54
with three condensed rings
605
with a bridged ring system
615
Adamantanes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
57
Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
26
containing rings other than six-membered aromatic rings
28
containing an adamantane ring system
Applicants:
NEUROVATION LABS, INC. [US/US]; 330 East 38th Street Unit 20C New York, NY 10016, US
Inventors:
PERUSINI, Jennifer, Nicole; US
Agent:
MACEDO, Charles, R.; US
AMOS, Brian, J.; US
Priority Data:
62/301,58329.02.2016US
Title (EN) DETECTION OF GLUA1 IN BRAIN TO IDENTIFY THE PRESENCE OF GLUA1 -MEDIATED PTSD
(FR) DÉTECTION DE GLUA1 DANS LE CERVEAU POUR IDENTIFIER LA PRÉSENCE D'UN ÉTAT DE STRESS POST-TRAUMATIQUE (ESPT) INDUIT PAR GLUA1
Abstract:
(EN) The present invention provides compositions and methods for detecting GluA1, as a subunit protein and/or as a GluA1 -containing, GluA2-lacking AMPAR complex. The invention further provides composition and methods for detecting and/or diagnosing PTSD. The invention further relates to compositions that can be detected using radiological imaging techniques, and processes for performing such imaging techniques using the compositions, to identify elevated GluA2 expression or activity in a subject, which is a biological marker of PTSD.
(FR) La présente invention concerne des compositions et des procédés de détection de GluA1, en tant que protéine de sous-unité et/ou complexe AMPAR contenant GluA1 et exempt de GluA2. L'invention concerne en outre une composition et des procédés de détection et/ou de diagnostic d'un état de stress post-traumatique (PTSD). L'invention concerne en outre des compositions qui peuvent être détectées à l'aide de techniques d'imagerie radiologique, et des procédés pour exécuter de telles techniques d'imagerie à l'aide des compositions, pour identifier une expression ou une activité de GluA2 élevée chez un sujet, qui est un marqueur biologique de ESPT.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)