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1. (WO2017151425) HSP90 INHIBITOR DRUG CONJUGATES
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Pub. No.: WO/2017/151425 International Application No.: PCT/US2017/019304
Publication Date: 08.09.2017 International Filing Date: 24.02.2017
IPC:
A61K 49/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
Applicants:
MADRIGAL PHARMACEUTICALS, INC. [US/US]; Four Tower Bridge 200 Barr Harbor Dive, Suite 400 West Conshohocken, Pennsylvania 19428, US
Inventors:
CHIMMANAMADA, Dinesh U.; US
KOSTIK, Elena; US
VUTUKURI, Dharma; US
YING, Weiwen; US
ZHANG, Junyi; US
Agent:
WARD, Donna T.; US
ZHU, Heng; US
Priority Data:
62/301,05229.02.2016US
Title (EN) HSP90 INHIBITOR DRUG CONJUGATES
(FR) CONJUGUÉS DE TYPE INHIBITEUR DE HSP90-MÉDICAMENT
Abstract:
(EN) The present invention provides Hsp90 drug conjugates (HDCs) comprising an Hsp90 ligand or prodrug thereof, a linker moiety and a payload moiety. The invention also provides methods for treating a disease or disorder in a subject, for example cancer, with an HDC.
(FR) La présente invention concerne des conjugués Hsp90-médicament (HDC) comprenant un ligand de Hsp90 ou son promédicament, un fragment lieur et un fragment charge utile. Des méthodes destinées à traiter une maladie ou un trouble chez un sujet, par exemple le cancer, à l'aide d'un HDC, sont en outre décrites.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)