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1. (WO2017151376) PIPERIDINE DERIVATIVE AND METHODS OF USE THEREOF
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Pub. No.: WO/2017/151376 International Application No.: PCT/US2017/019050
Publication Date: 08.09.2017 International Filing Date: 23.02.2017
IPC:
C07D 401/14 (2006.01) ,A61P 25/00 (2006.01) ,A61P 29/00 (2006.01) ,A61K 31/4545 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
4545
containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
Applicants:
VTV THERAPEUTICS LLC [US/US]; 4170 Mendenhall Oaks Parkway High Point, NC 27265, US
Inventors:
MJALLI, Adnan M.M.; US
HARI, Anitha; US
GADDAM, Bapu; US
CHRISTEN, Daniel; US
POLISETTI, Dharma, Rao; US
BANNER, William, Kenneth; US
GOWDA, Raju, Bore; US
ANDREWS, Robert, Carl; US
GUPTA, Suparna; US
Agent:
ROLLINS, Samuel, B.; US
Priority Data:
62/301,74801.03.2016US
Title (EN) PIPERIDINE DERIVATIVE AND METHODS OF USE THEREOF
(FR) DÉRIVÉ PIPÉRIDINE ET SES MÉTHODES D'UTILISATION
Abstract:
(EN) The present invention provides N-[1-(1-Cyclohexyl-3,5-dimethyl-1H-pyrazole-4-sulfonyl)-4-phenyl-piperidin-4-ylmethyl]-N-isobutyl-4-{[(piperidin-4-ylmethyl)-amino]-methyl}-benzenesulfonamide and pharmaceutically acceptable salts thereof. These compounds may be useful in the treatment of diseases such as Alzheimer's disease or renal failure. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating certain diseases.
(FR) La présente invention concerne un N-[1-(1-cyclohexyl-3,5-diméthyl-1H-pyrazole-4-sulfonyl)-4-phényl-pipéridin-4-ylméthyl]-N-isobutyl-4-{[(pipéridin-4-ylméthyl)-amino]-méthyl}-benzènesulfonamide et des sels pharmaceutiquement acceptables de celui-ci. Ces composés peuvent être utiles dans le traitement de maladies telles que la maladie d'Alzheimer ou une insuffisance rénale. L'invention concerne en outre des procédés de préparation de composés représentés par la formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, des compositions pharmaceutiques comprenant de tels composés, et l'utilisation de tels composés et/ou compositions pharmaceutiques dans le traitement de certaines maladies.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)