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1. (WO2017151360) SPHINGOSINE KINASE INHIBITORS AND CERAMIDE FOR MAINTENANCE THERAPY OF GLIOBLASTOMA

Pub. No.:    WO/2017/151360    International Application No.:    PCT/US2017/018889
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Thu Feb 23 00:59:59 CET 2017
IPC: A61K 31/133
A61K 31/137
A61K 31/164
A61K 31/167
Applicants: SIGNPATH PHARMA, INC.
Inventors: HELSON, Lawrence
SORDILLO, Laura, A.
SORDILLO, Peter
Title: SPHINGOSINE KINASE INHIBITORS AND CERAMIDE FOR MAINTENANCE THERAPY OF GLIOBLASTOMA
Abstract:
The present invention includes methods of preventing a ceramide-sensitive cancer comprising: identifying a subject that has been treated for the ceramide-sensitive cancer; and providing to the subject an effective amount of a combination of a sphingosine kinase inhibitor and a ceramide inducing agent or a ceramide analog in an amount sufficient to prevent or reduce the recurrence of the ceramide-sensitive cancer.