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1. (WO2017151176) ANTIBODIES TO CD40 WITH ENHANCED AGONIST ACTIVITY

Pub. No.:    WO/2017/151176    International Application No.:    PCT/US2016/039785
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Jun 29 01:59:59 CEST 2016
IPC: C07K 16/28
A61K 39/00
Applicants: THE ROCKEFELLER UNIVERSITY
Inventors: RAVETCH, Jeffrey, V.
DAHAN, Rony
Title: ANTIBODIES TO CD40 WITH ENHANCED AGONIST ACTIVITY
Abstract:
Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcϒRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.