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1. (WO2017151063) USE OF FURAZANO[3,4-B]PYRAZINE DERIVATIVES FOR CHEMOTHERAPY

Pub. No.:    WO/2017/151063    International Application No.:    PCT/SG2017/050104
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: A61K 31/4985
A61P 35/00
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventors: CHEOK, Chit Fang
CORONEL, Luis
Title: USE OF FURAZANO[3,4-B]PYRAZINE DERIVATIVES FOR CHEMOTHERAPY
Abstract:
The present invention relates to methods of treating cancer with a mitochondrial uncoupler comprising a furazano[3,4 b]pyrazine. The present invention also relates to methods of using the said mitochondrial uncoupler, and the uses thereo to develop target-specific therapeutic agents. In a preferred embodiment, the mitochondrial uncoupler is N5,N6-bis(2 fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (BAM15). Also provided is a pharmaceutical composition comprising said mitochondrial uncoupler and a second therapeutic agent, wherein the second therapeutic agent preferably also is used in the treatment of cancer.