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1. (WO2017151018) BENZO[D]ISOXAZOLE DERIVATIVES AND APPLICATION THEREOF

Pub. No.:    WO/2017/151018    International Application No.:    PCT/RU2017/050007
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Tue Feb 28 00:59:59 CET 2017
IPC: C07D 261/20
C07D 413/06
C07D 413/10
C07D 413/12
C07D 413/14
C07D 417/12
A61K 31/427
A61K 31/4427
A61K 31/42
A61P 7/00
Applicants: OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOSTYU "SAI FARMA"
ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ «САЙ ФАРМА»
Inventors: CHILOV, Germes Grigorievich
ЧИЛОВ, Гермес Григорьевич
STROGANOV, Oleg Valentinovich
СТРОГАНОВ, Олег Валентинович
TITOV, Ilya Yurievich
ТИТОВ, Илья Юрьевич
NOVIKOV, Fedor Nikolaevich
НОВИКОВ, Федор Николаевич
STROILOV, Viktor Sergeevich
СТРОЙЛОВ, Виктор Сергеевич
Title: BENZO[D]ISOXAZOLE DERIVATIVES AND APPLICATION THEREOF
Abstract:
The invention relates to the chemistry of organic compounds, pharmacology and medicine, and pertains to the prevention and/or treatment of a state in mammals characterized by undesirable thrombosis, and, in particular, thromboses, thromboembolism and other diseases accompanied by thrombosis formation, using a novel class of chemical compounds exhibiting increased effectiveness in inhibiting therapeutically significant proteases, a coagulation factor of XIa, and also enhanced selectivity and bioavailability. In order to achieve the above, the compounds of general formula (I) are proposed, in which R1; R2, R3, L1, and cycle A have values indicated in the description. The invention also relates to pharmaceutical compositions containing the indicated compounds, and also to the application of the aforementioned compounds for treating and/or preventing a state in mammals characterized by undesirable thrombosis.