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1. (WO2017150997) COMPOUND, PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL SOLUTION CONTAINING THE COMPOUND, A METHOD OF DETERMINING THE PRESENCE OF CANCER, A KIT FOR CANCER DETECTION, AND THE USE OF HYDROLYSIS OF THE COMPOUND FOR THE DETECTION OF CANCER

Pub. No.:    WO/2017/150997    International Application No.:    PCT/PL2017/000018
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 04 00:59:59 CET 2017
IPC: A61K 49/00
C07K 5/11
Applicants: INSTYTUT BIOTECHNOLOGII I MEDYCYNY MOLEKULARNEJ
Inventors: LESNER, Adam
WYSOCKA, Magdalena
NIDZWORSKI, Dawid
Title: COMPOUND, PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL SOLUTION CONTAINING THE COMPOUND, A METHOD OF DETERMINING THE PRESENCE OF CANCER, A KIT FOR CANCER DETECTION, AND THE USE OF HYDROLYSIS OF THE COMPOUND FOR THE DETECTION OF CANCER
Abstract:
The subject of the invention is a new compound of the following chemical formula: ABZ1 -Dap(02(Cbz))2-Dap(01 )3-Dap(02)4-Arg5-ANB6-NH2 where: ABZ stands for 2-aminobenzoic acid; DAP stands for diaminopropanoic acid (Dap) derivatives, modified by the functionalised residues of mono- ethyl ene or diethyl ene glycol (PEG); ANB stands for 5-amino-2-nitrobenzoic acid The subject of the invention is a method for producing the new compound and a phamiaceutical solution for cancer detection, which contains the above-mentioned compound. The subject of the invention is a method for cancer detection through the in vitro analysis of a human urine sample to which a new compound is added and blended with a buffer of pH 7-9. The subject of the invention is also a kit for detecting cancer, in particular bladder cancer, and the use of hydrolysis of the new compound in the position no. 5 by proteasome 20s for cancer detection, in particular bladder cancer.