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1. (WO2017150704) AQUAPORIN 4 FUNCTION PROMOTER AND PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS
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Pub. No.: WO/2017/150704 International Application No.: PCT/JP2017/008485
Publication Date: 08.09.2017 International Filing Date: 03.03.2017
IPC:
A61K 31/44 (2006.01) ,A61K 31/443 (2006.01) ,A61K 31/4433 (2006.01) ,A61K 31/4439 (2006.01) ,A61P 9/00 (2006.01) ,A61P 25/00 (2006.01) ,A61P 25/28 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
443
containing a five-membered ring with oxygen as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4433
containing a six-membered ring with oxygen as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
国立大学法人新潟大学 NIIGATA UNIVERSITY [JP/JP]; 新潟県新潟市西区五十嵐二の町8050番地 8050, Ikarashi ni-nocho, Nishi-ku, Niigata-shi, Niigata 9502181, JP
Inventors:
中田 力 NAKADA Tsutomu; JP
フーバー ビンセント HUBER Vincent; JP
五十嵐 博中 IGARASHI Hironaka; JP
鈴木 雄治 SUZUKI Yuji; JP
クィー イングリッド KWEE Ingrid; JP
Agent:
棚井 澄雄 TANAI Sumio; JP
松沼 泰史 MATSUNUMA Yasushi; JP
及川 周 OIKAWA Shu; JP
大槻 真紀子 OTSUKI Makiko; JP
Priority Data:
2016-04276604.03.2016JP
Title (EN) AQUAPORIN 4 FUNCTION PROMOTER AND PHARMACEUTICAL COMPOSITION FOR NEUROLOGICAL DISORDERS
(FR) ACTIVATEUR DE LA FONCTION DE L'AQUAPORINE 4 ET COMPOSITION PHARMACEUTIQUE POUR TROUBLES NEUROLOGIQUES
(JA) アクアポリン4機能促進剤及び神経疾患用の医薬組成物
Abstract:
(EN) An aquaporin 4 function promoter contains, as an active ingredient, a compound represented by general formula (1) or (2) or a pharmacologically acceptable salt thereof. (In the formulas, n11 is an integer of 1-10. R21 is a C1-10 alkyl group, alicyclic heterocyclic group, aromatic hydrocarbon group, or aromatic heterocyclic group.)
(FR) L'invention concerne un activateur de la fonction de l'aquaporine 4, qui contient, comme principe actif, un composé représenté par la formule générale (1) ou (2) ou un sel pharmacologiquement acceptable de celui-ci. (Dans les formules, n11 représente un entier de 1 à 10, R21 représente un groupe alkyle en C1 à C10, un groupe hétérocyclique alicyclique, un groupe hydrocarboné aromatique ou un groupe hétérocyclique aromatique).
(JA) アクアポリン4機能促進剤は、下記一般式(1)若しくは(2)で表される化合物、又はその薬学的に許容できる塩を有効成分として含有する。 (式中、n11は1~10の整数である。R21は炭素数1~10のアルキル基、脂環式複素環基、芳香族炭化水素基、又は芳香族複素環基である。)
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)