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1. (WO2017150681) AMYOTROPHIC LATERAL SCLEROSIS DIAGNOSTIC METHOD USING SIGNAL PEPTIDE AS INDEX

Pub. No.:    WO/2017/150681    International Application No.:    PCT/JP2017/008332
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Fri Mar 03 00:59:59 CET 2017
IPC: G01N 27/62
G01N 33/68
C07K 7/00
Applicants: TOAGOSEI CO.,LTD.
東亞合成株式会社
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
国立大学法人名古屋大学
Inventors: BAILEYKOBAYASHI Nahoko
ベイリー小林 菜穂子
SAWADA, Makoto
澤田 誠
YOSHIDA Tetsuhiko
吉田 徹彦
Title: AMYOTROPHIC LATERAL SCLEROSIS DIAGNOSTIC METHOD USING SIGNAL PEPTIDE AS INDEX
Abstract:
This method assists in the detection of ALS and involves determining the profile of signal peptides contained in a bodily fluid derived from a subject being examined, and comparing said determined signal peptide profile of the subject being examined with the profile of signal peptides in the bodily fluid derived from a pre-determined healthy subject. Further, this method is characterized in that a difference at a specific molecular weight between the signal peptide profile of the subject being examined and the signal peptide profile of the healthy subject is associated with the subject being examined suffering from or developing ALS.