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1. (WO2017150637) ARTIFICIAL RED BLOOD CELL HAVING ABILITY TO INHIBIT TRANSFORMATION OF HEMOGLOBIN INTO METHEMOGLOBIN
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Pub. No.: WO/2017/150637 International Application No.: PCT/JP2017/008187
Publication Date: 08.09.2017 International Filing Date: 01.03.2017
Chapter 2 Demand Filed: 20.06.2017
IPC:
A61K 38/16 (2006.01) ,A61K 9/127 (2006.01) ,A61K 47/16 (2006.01) ,A61K 47/24 (2006.01) ,A61K 47/28 (2006.01) ,A61K 47/34 (2017.01) ,A61P 7/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
24
containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
28
Steroids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
08
Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Applicants:
公立大学法人奈良県立医科大学 PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY [JP/JP]; 奈良県橿原市四条町840 840, Shijo-cho, Kashihara-shi, Nara 6348521, JP
Inventors:
酒井 宏水 SAKAI Hiromi; JP
山田 孫平 YAMADA Magohei; JP
Agent:
特許業務法人小田島特許事務所 PATENT PROFESSION CORPORATION ODAJIMA PATENT OFFICE; 東京都千代田区永田町2-4-3永田町ビル 8階 Nagatacho Building, Nagatacho 2-4-3, Chiyoda-ku, Tokyo 1000014, JP
Priority Data:
2016-04049402.03.2016JP
Title (EN) ARTIFICIAL RED BLOOD CELL HAVING ABILITY TO INHIBIT TRANSFORMATION OF HEMOGLOBIN INTO METHEMOGLOBIN
(FR) GLOBULES ROUGES ARTIFICIELS PERMETTANT D'INHIBER LA TRANSFORMATION DE L'HÉMOGLOBINE EN MÉTHÉMOGLOBINE
(JA) ヘモグロビンのメト化抑制能を有する人工赤血球
Abstract:
(EN) The present invention inhibits, in an artificial red blood cell containing purified and enriched hemoglobin that substantially has no enzymatic activity to reduce methemoglobin, transformation of the hemoglobin into methemoglobin. Provided is an artificial red blood cell which comprises: an aqueous solution that contains NADH and/or NADPH and hemoglobin; and a capsule that includes the aqueous solution, wherein the aqueous solution and the capsule substantially have no enzymatic activity to reduce methemoglobin.
(FR) La présente invention inhibe la transformation de l'hémoglobine en méthémoglobine dans des globules rouges artificiels contenant de l'hémoglobine purifiée et enrichie qui n'a pratiquement pas d'activité enzymatique permettant de réduire la méthémoglobine. La présente invention concerne des globules rouges artificiels qui comprennent : une solution aqueuse qui contient du NADH et/ou du NADPH et de l'hémoglobine ; et une capsule qui comprend la solution aqueuse, ladite solution aqueuse et ladite capsule n'ayant pratiquement aucune activité enzymatique permettant de réduire la méthémoglobine.
(JA) メトヘモグロビンを還元する酵素活性が実質的にない精製濃縮ヘモグロビンを含む人工赤血球において、ヘモグロビンのメト化を抑制する。 NADH及び/又はNADPHと、ヘモグロビンとを含む水溶液と、該水溶液を内包するカプセルとからなり、前記水溶液及びカプセルはメトヘモグロビンを還元する酵素活性が実質的にない、人工赤血球を提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)