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1. (WO2017149745) METHOD FOR ASSESSING PAIN CAUSED BY ADMINISTRATION OF DRUG SOLUTION, AND METHOD FOR SELECTING DRUG SOLUTION ADMINISTRATION

Pub. No.:    WO/2017/149745    International Application No.:    PCT/JP2016/056741
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Mar 05 00:59:59 CET 2016
IPC: G01N 33/483
Applicants: TERUMO KABUSHIKI KAISHA
テルモ株式会社
Inventors: AMI, Nozomi
網のぞみ
TAMATSUKURI, Shigeru
玉造滋
Title: METHOD FOR ASSESSING PAIN CAUSED BY ADMINISTRATION OF DRUG SOLUTION, AND METHOD FOR SELECTING DRUG SOLUTION ADMINISTRATION
Abstract:
In a method for assessing pain caused by the administration of a drug solution, a rat (12) is provided, the rat (12) is anesthetized by inhalation anesthesia, a measurement electrode (24) is placed in the semitendinosus muscle (12b) of the anesthetized rat (12), an injection needle (18) is punctured under the plantar skin surface (12a) of the anesthetized rat (12) while measuring the muscle potential in the semitendinosus muscle (12b) with the measurement electrode (24), a drug solution is administered to the anesthetized rat (12) through the injection needle (18) after a myoelectric reaction caused by the punctuation of the injection needle (18) disappears, and at least one of the measurement of the duration time (T) of the myoelectric reaction caused by the administration of the drug solution and the measurement of the EMG intensity, which is produced by integrating absolute values of muscle potentials during the period between the onset of the myoelectric reaction by the administration of the drug solution to the disappearance of the myoelectric reaction, is carried out.